The best Side of pentobarbital drug
The best Side of pentobarbital drug
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Remark: Barbiturates may increase adverse effects, including respiratory melancholy, produced by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.
pentobarbital improves effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers may possibly boost metabolism of ifosfamide to its metabolite. Check for elevated effects/toxicities if combined with CYP2B6 inducers.
pentobarbital will lessen the level or outcome of prednisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lower the extent or influence of fesoterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will reduce the level or effect of levoketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
Contraindicated (one)pentobarbital will decrease the extent or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Stay away from; coadministration with CYP3A inducers may perhaps lead to diminished plasma concentrations of elvitegravir and/or even a concomitantly administered protease inhibitor and bring about lack of therapeutic influence and also to probable resistance
pentobarbital will boost the amount or outcome of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will minimize the level or outcome of efavirenz by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will reduce the extent or impact of diclofenac by influencing hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Unidentified.
pentobarbital will reduce the extent or impact of terbinafine here by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
buprenorphine subdermal implant and pentobarbital each improve sedation. Keep away from or Use Alternate Drug. Limit use to people for whom alternative treatment solutions are inadequate
pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of CYP3A4 inducers may well reduce sufentanil amounts and efficacy, perhaps precipitating withdrawal syndrome in individuals who may have produced physical dependence to sufentanil. Discontinuation of concomitantly made use of CYP3A4 inducers may increase sufentanil plasma focus.
pentobarbital will lessen the extent or influence of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.